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Only metabolite M7 was detected in the 1–3 cm sections, and its focus was lower than the LLOQ. The metabolites M2 and M7 were detected at 4–6 cm, and their concentrations were additionally decrease than the LLOQ. The validated method was utilized to 4 genuine forensic instances.
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Synthetic cannabinoids are normally monitored by analyzing the mother or father drug and its metabolites in blood and urine samples (Presley et al., 2016; Krotulski et al., 2019). Currently, hair is likely one of the key sample matrices for figuring out drug abuse within the subject of forensic science (Salomone et al., 2014). However, few studies have examined artificial cannabinoids and their metabolites in human hair. Like other indazole artificial cannabinoids, this chemical binds to the human CB1 and CB2 receptors, creating a range of sensory and physiological effects. For this reason, it and plenty of related comounds have seen use as recreational chemicals or so referred to as designer medication. This study describes the development and validation of an LC-MS/MS process for the identification and quantification of 5F-MDMB-PICA and its metabolites in human hair.
